The functional `G' cell mass in atrophic gastritis

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The functional 'G' cell mass in atrophic gastritis.

The serum gastrin response to a standard protein meal has been determined in achlorhydric patients with atrophic gastritis and contrasted with the response in normal subjects whose gastric contents were kept continuously neutral by intragastric bicarbonate instillation. Five normal subjects showed a significant increase in serum gastrin from a mean (+/- SEM) of 17 +/- 3 pg/ml to 119 +/- 10 pg/m...

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Progressive increase in the functional G cell mass with age in atrophic gastritis.

Patients with atrophic gastritis but normal antral mucosa and achlorhydria were divided into three groups according to age-under 40, 40 to 70, and over 70 years. Serum gastrin, both basal and following a standard protein meal, was estimated in all patients by radioimmunoassay. There was a significant correlation between the magnitude of the gastrin response and age, the older the patient the gr...

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Morpho-functional comparisons in Helicobacter pylori-associated chronic atrophic gastritis.

PURPOSE To evaluate serum pepsinogen I (PG I) and gastrin-17 (G-17) levels in patients with Helicobacter pylori (H. pylori)-associated chronic atrophic gastritis, with reference to endoscopical Kimura-Takemoto's staging, chromoendoscopical and histological features. MATERIAL AND METHODS 267 dyspeptic H. pylori-infected patients were examined by chromoendoscopy with biopsy sampling according t...

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Autoimmune atrophic gastritis: current perspectives

At present there is no universally accepted classification for gastritis. The first successful classification (The Sydney System) that is still commonly used by medical professionals was first introduced by Misiewicz et al in Sydney in 1990. In fact, it was the first detailed classification after the discovery of Helicobacter pylori by Warren and Marshall in 1982. In 1994, the Updated Sydney Sy...

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Atrophic gastritis in young children and adolescents.

BACKGROUND Helicobacter pylori associated gastric cancer arises via a multistage process, with atrophic gastritis being the precursor lesion. Helicobacter pylori is typically acquired in childhood, yet little is known of the prevalence of atrophic gastritis in childhood. AIM To study atrophic gastritis among children from countries with high gastric cancer incidence. METHODS Sections from t...

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ژورنال

عنوان ژورنال: Gut

سال: 1972

ISSN: 0017-5749

DOI: 10.1136/gut.13.5.349